AKT1 and acute myeloid leukemia: The results showed that preferential OXPHOS metabolism of AML cells is associated with constitutive co-activation of AMPK and mTORC1 and increased autophagy, while a glycolytic profile is mainly associated with AKT/mTORC1 activation and low autophagy flux, highlighting the relevance of signaling pathways and autophagy on metabolic reprograming of AML [12].