For examples, SAM domain- and HD domain-containing protein 1 (SAMHD1) inhibits HIV-1 infection of dendritic cells [2,3] and T cells [4,5] by reducing the cellular deoxynucleoside triphosphate (dNTP) concentration to a level at which the viral reverse transcriptase cannot function [2,6]. This evidence concerns the gene SAMHD1 and HIV-1 infection.