Furthermore, in nasopharyngeal carcinoma, PLAC8 contributes to radioresistance by inhibiting the PI3K/AKT/GSK3β pathway, as knockout of PLAC8 sensitizes nasopharyngeal carcinoma cells to radiation by activating the PI3K/AKT/GSK3β pathway. Here, AKT1 is linked to nasopharyngeal carcinoma.