In addition, AKT phosphorylates a host of cellular proteins, including GSK3β, mTOR and NF‐κB, to facilitate cell survival and apoptosis.37, 38, 39 To confirm whether PLAC8 regulates BC proliferation through the PI3K pathway, we analysed the expression of PI3k/AKT/NF‐κB pathway markers, the results of which were consistent with the observed changes in PLAC8 expression. The gene discussed is AKT1; the disease is breast cancer.