TGFB1 and breast cancer: For example, miR‐613 acts as an upstream regulator that disturbs the interaction between YAP and WBP2, influencing the activity of the EGFR/PI3K pathway in triple‐negative BC cells.34 Similarly, cPLA2α has been shown to activate PI3k/Akt signalling to mediate the TGF‐β‐induced EMT in BC cells.36 PI3K has been linked to an extraordinarily diverse group of cellular functions via the activation of Akt.