Craciun et al identified CDH11, MRC1 and PLTP as biomarkers of kidney fibrosis by RNA sequencing.47 Lee et al analysed the transcriptome complexity through RNA sequencing in normal and failing murine hearts.48 However, few studies have identified the profiles of differentially expressed circRNAs under drug action using RNA sequencing in progressive lung fibrosis. The gene discussed is PLTP; the disease is pulmonary fibrosis.