GC development under 50 years of age is probably followed by family history.10 People with a positive paternal family history were at higher risk of GC compared to positive maternal family history.11 Coexistence of two risk factors including a positive family history and infection with a CagA‐positive H pylori isolate could increase more than 16‐fold risk of NCGA and eightfold total risk of CGA.12 Thus, identifying inherited parameters among subjects with GC family histories is an important step for due diagnosis and management of the disease. Here, S100A8 is linked to gastric cancer.