Two ligands of PD‐1, programmed death‐1 ligand 1 (PD‐L1) and PD‐L2, inhibit activation and proliferation of T cells, leading to tumor escape from immune surveillance.64 A considerable increased risk of CGA related with the PD‐1 rs2227982 C>T polymorphism was observed among ever drinking subjects (TT vs CC: OR = 2.53, TT+CT vs CC: OR = 2.04).65 According to TCGA, PD‐L1 gene was frequently amplified in EBV‐positive GC, probably indicating the higher immunogenicity of this GC subclass. Here, CD274 is linked to neoplasm.