According to the previous studies, some CRC biomarkers, including miR‐29, miR‐92a, miR‐106, and other miRNAs, also took part in some important pathways that were involved by miR‐181 such as miRNAs in cancer, FoxO signaling, pathways in cancer, proteoglycans in cancer, colorectal cancer signaling, and PI3K‐Akt signaling.45, 46, 47 It may suggest that these cellular signaling that can lead to poor prognosis of CRC may be modulated by a series of miRNA biomarkers. The gene discussed is AKT1; the disease is cancer.