It was indicated from the results that the genes targeted by miR‐181a and miR‐181b were involved in similar pathways closely related to CRC initiation and development, such as miRNAs in cancer, MAPK, pathways in cancer, FoxO, VEGF, colorectal cancer, HIF‐1, PI3K‐Akt, mTOR, and central carbon metabolism in cancer. The gene discussed is AKT1; the disease is colorectal carcinoma.