Saladi et al. (2017) discovered negative regulation of WWC1, the inhibitor of YAP nuclear localization, by the physical interaction of p63 with a chromatin remodeling factor- ACTL6A, resulting in activation of YAP signaling, induction of regenerative state, and tumorigenesis in head-and-neck squamous cell carcinoma (Figure 2C). The gene discussed is YAP1; the disease is head and neck squamous cell carcinoma.