TP53 and gastric cancer: Additionally, in a human gastric cancer cell line, MGC-803, harboring TP53 mutations, it was shown that knock-down of long intergenic non-coding RNA p21 (lincRNA-p21), a direct transcriptional target of p53, induced epithelial to mesenchymal transition state and metastasis by elevating YAP expression suggesting that lincRNA-p21 represses YAP expression downstream of p53 (Chen et al., 2017).