For example, one report showed that the TAp63 isoform can function as tumor suppressor in breast cancer as loss of TAp63 promotes transition of mammary epithelial cells into tumor-initiating cells through expression of mammary stem cell-related gene signature, partly via the upregulation of TAZ, a YAP paralog and transducer of the Hippo pathway (Su et al., 2017). Here, YAP1 is linked to breast carcinoma.