Under apoptosis triggered by anti-cancer drugs, YAP recruits both promyelocytic leukemia (PML) and p300 transcriptional coactivators, concomitantly, at specific p73 apoptotic target genes such as TP53AIP1 and BAX, to promote p73-dependent apoptotic response (Figure 2D) (Strano et al., 2005; Lapi et al., 2008). The gene discussed is YAP1; the disease is cancer.