Studies on an interesting hyperactive “super-tumor suppressor” p53 mutant (p53W53Q,F54S; henceforth referred to as p5353,54), harboring double point mutations in the critical hydrophobic residues within the second transactivation domain of p53, have helped uncover a tyrosine phosphatase called PTPN14, an inhibitor of YAP, as a central component of the p53 tumor suppression pathway (Michaloglou et al., 2013; Raj and Attardi, 2017). The gene discussed is TP53; the disease is neoplasm.