Recent advances in imaging transport within the living brains of transgenic mice using manganese-enhanced magnetic resonance imaging (MEMRI) are elucidating relationships between AD, APP expression, presence of plaques and transport dynamics (Bearer et al., 2007; Simmons et al., 2008; Chuang et al., 2009; Gallagher et al., 2012; Majid et al., 2014; Medina et al., 2017). Here, APP is linked to Alzheimer disease.