IRF3 and infection: At early time point, 12 and 24 h post JEV infection, the p-AKT/AKT and p-IRF3/IRF3 proteins were shown to be up-regulated, whereas at later stages of the infection progress (at 48 h), the expression of p-AKT/AKT and p-IRF3/IRF3 have shown the decreasing trend (Figures 1C–F).