TLR2 and periodontitis: Furthermore, the activation of TLR2 and TLR4 are found to be related with gingivitis and periodontitis in vivo (Yoshioka et al., 2008; Ilango et al., 2016), in line with our study where we found that the gingivitis biofilm induced more upregulation of TLR4 transcription compared to commensal and cariogenic biofilms.