The transcription of miR-141 and miR-200c might be directly suppressed by ZEB1, which could strongly activate epithelial differentiation of pancreatic, colorectal and breast cancer cells (30, 31).The ectopic expression of miR-93 might promote cell proliferation, migration, invasion, EMT and formation of tumor while it inhibited cell apoptosis and G1 cell cycle arrest (32). This evidence concerns the gene ZEB1 and breast carcinoma.