Besides HLA I downregulation, other evasive influences shared by HL (183, 184), NPC (185), gastric carcinoma (186), and most recently T/NK cell disease (187) include infiltration by myeloid-derived suppressor cells (MDSCs), secretion of immunosuppressive cytokines such as IL10, and high level expression of the T cell-inhibitory programme death ligand (PDL)-1 (174). This evidence concerns the gene CD274 and Hodgkins lymphoma.