Firstly the recognition of a hyper-methylated EBV genome as a defining characteristic of virus-positive gastric carcinoma (164, 165) is awakening/reawakening interest in the methylation status of other tumors, especially NPC and the T/NK lymphomas (116) and in EBV's potential as a driver of epigenetic change; in this context, both LMP1 (191) and LMP2A (166) have been implicated as activators of DNA methyl transferases in epithelial cell systems. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.