We also validated the expression of four important AML specific RBP genes, CLK4, ERI1, NSUN7 and RBM47. In conclusion, our study aims to provide a comprehensive picture of the expression and function of RBPs in myelopoiesis and leukemic transformation and highlights their importance as potential candidates for therapeutic intervention toward effective eradication of LSCs in AML. The gene discussed is CLK4; the disease is acute myeloid leukemia.