In general, CML is well-known as a disease sensitive to immunological control, as evidenced by the fact that immune responses against CML-specific and CML-associated antigens such as BCR-ABL1, proteinase-3, and WT-1 can be detected in CML patients (48) and donor lymphocyte infusions are able to induce long-lasting remissions in relapsed CML patients after allogeneic SCT (49). This evidence concerns the gene PRTN3 and chronic myelogenous leukemia, BCR-ABL1 positive.