ERBB2 and non-small cell lung carcinoma: Previous studies are mainly concentrated on ERBB2-mutated metastatic NSCLC (42), to our knowledge, our study is the first to show ERBB2 amplification is associated with the resistance of adjuvant chemtherapy and recurrence in LUAD patients, monoclonal antibody trastuzumab and pertuzumab which target ERBB2 may help guide therapeutic strategies for post-operative relapse for LUAD.