The possible connection between clinico-pathological stages and gene expression patterns for the AD risk factor genes among theAPOE4-positive andAPOE4-negative females and males was investigated (Extended data Workbooks 8 to 14, Workbook 1:CNTNAP2, Workbook 2:PSEN2, Workbook 3:APOE, Workbook 4:PSEN1, Workbook 5:APP, Workbook 6,ADAM10, Workbook 7:TREM2). Here, APOE is linked to Alzheimer disease.