NLRP3 and atherosclerosis: Dyslipidemia, especially exposure to saturated fatty acids, induces endoplasmic reticulum stress, mitochondrial oxidative stress, and elF2 alpha phosphorylation which hyperactivates an integrated stress response (ISR), which in turn activates a local and systemic inflammatory response through activation of NLRP3 inflammasome: this process contributes to atherogenesis since inhibition of ISR at different nodes reduces atherosclerosis in hyperlipidemic murine models22.