TLR4 and dengue disease: Dengue NS1 has been shown to activate complement by the alternative pathway, target liver cells promoting intracellular DENV infection, complex with thrombin in acute-phase blood of severe dengue, activate plateletsin vitro via Toll-like-receptor 4 (TLR4), and produce thrombocytopenia in TLR4 knockout and normal mice90–93.