While Kv1.3 inhibition has been reported to induce apoptosis in B-CLL cells [62], we did not observe increased apoptosis following Kv1.3 blockade in malignant T cells (Figure 4A and 4B), which is consistent with previous reports showing that ShK does not induce apoptosis in healthy T cells [57]. Here, SHPK is linked to B-cell chronic lymphocytic leukemia.