AKT1 and Familial prostate cancer: In prostate cancer, PTK6 contributes to increased phosphorylation and activation of its substrates, such as AKT serine/threonine kinase 1 (AKT), CAS scaffolding protein family member 1 (p130CAS), and focal adhesion kinase (FAK), thereby promoting the tumor progression (Zheng and Tyner, 2013).