While these are indisputably important mechanisms of persistence, we propose that interactions between reservoir-harboring cells and CD8+ T cells are also likely to occur at some frequency in individuals on long-term ART (see Is Immune Selection Pressure Exerted on Infected Cell Clones During ART?, below), providing the potential for the shaping of the landscape of reservoir harboring cells in ways which may parallel tumor immunoediting. This evidence concerns the gene CD8A and neoplasm.