Recently, butyrate was shown to regulate the expression of tumor-suppresive miRNAs (miRNA-26a,-26a-1,-192, etc.)through the bile acid nuclear receptor, farnesoid X receptor (FXR) while also promoting hepatocyte apoptosis through miR-22 up-regulation in hepatic cells (Pant et al., 2017; reviewed in Feng Q. et al., 2018). Here, NR1H4 is linked to neoplasm.