GH1 and hypopituitarism: Due to these contradictory results and scarce studies with the gold standard method to evaluate insulin sensitivity, euglycemic hyperinsulinemic clamp, we performed a study using this method in patients with hypopituitarism without growth hormone replacement compared to a control group composed by individuals with normal pituitary function paired by BMI, gender, and age and additionally, we evaluated the characteristics of body composition in these groups.