Due to these contradictory results and scarce studies with the gold standard method to evaluate insulin sensitivity, euglycemic hyperinsulinemic clamp, we performed a study using this method in patients with hypopituitarism without growth hormone replacement compared to a control group composed by individuals with normal pituitary function paired by BMI, gender, and age and additionally, we evaluated the characteristics of body composition in these groups. This evidence concerns the gene INS and hypopituitarism.