Indeed, plasma levels of interferon-γ (IFN-γ, a cytokine regulating immune and inflammatory responses intervening in the pathogenesis of a number of brain diseases, Blasko et al., 2001) are correlated with age-related disturbance of circadian rhythms and survival: high levels of IFN-γ are associated with a short lifespan and a short free-running period tau; IFN-γ levels also correlate with characteristic patterns of LA and body temperature during aging (high percentage of diurnal LA, advanced onset, delayed occurrence of minimal Tc, Cayetanot et al., 2009). The gene discussed is IFNG; the disease is brain disorder.