ITGAM and acute kidney injury: On the other hand, the reduction of M1 Mφ by clodronate injection (Lu et al., 2008) and by DT injection in Cd11b-DTR mice (± clodronate) did not show any effect on cisplatin- and ischemia-induced AKI, respectively (Ferenbach et al., 2012; Lu et al., 2012) (Table 2).