SIRT4 and type 2 diabetes mellitus: The findings for the T2D group showed that SIRT4 mRNA expression in peripheral blood leukocytes was negatively correlated with high-density lipoprotein cholesterol (HDL) level and positively correlated with triglyceride/lipoprotein a level (Song et al., 2011); absence of SIRT4 is likely to enhance the development of T2D (Mahlknecht and Voelter-Mahlknecht, 2009).