GRK2 and myocardial infarction: Hence, in the present study, we tested the impact of aldosterone stimulation, and the role of GRK2, on both insulin and βAR signaling in vitro, in fibroblasts (3T3 cells), and in vivo, in mice undergoing chronic aldosterone infusion or surgical-induced myocardial infarction (MI), two models of hyperaldosteronism (Cannavo et al., 2016).