According to the western blot results, the relative expression of p-PI3K/t-PI3K, p-AKT/t-AKT, and p-mTOR/t-AKT was increased in the DKD groups and decreased in the CaD treatment groups (KK-Ay+CaD and HFD/STZ+CaD) (Figures 4A–F). This evidence concerns the gene AKT1 and diabetic kidney disease.