Our transcriptomic studies on muscle biopsies in ALS patients showed a significant increase in the expression of the UGCG gene (UDP-glucose ceramide glucosyltransferase), encoding the sphingolipid metabolism enzyme that synthesizes glucosylceramide (GlcCer) (Henriques et al., 2015; Dodge, 2017; Henriques et al., 2017). Here, UGCG is linked to amyotrophic lateral sclerosis.