For example, PNPLA3 rs738409 GG gene variant carriers have 73% more liver fat than non-carriers (Sookoian and Pirola, 2011), but are not more likely to have T2D according to the NASH CRN database (Speliotes et al., 2010) and Shanghai Changfeng Study (Xia et al., 2016); only a small increase in the risk of T2D was observed in 100,323 people from a publicly available T2D genome-wide association studies (GWAS) database (OR 1.04 [1.01−1.07], P = 0.0045) (Dongiovanni et al., 2018). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.