Under conditions of hepatic insulin resistance, the de novo lipogenesis can be stimulated both by insulin, via sterol regulatory element-binding-protein 1c (SREBP-1c) (Tian et al., 2016), and by glucose, via carbohydrate response element-binding protein (ChREBP) (Linden et al., 2018). The gene discussed is MLXIPL; the disease is Insulin resistance.