The first evidence for the development of NAFLD in the absence of glucose metabolism disorders was found in a mouse model with overexpression of diacylglycerol acyltransferase 2 (DGAT2), an enzyme catalyzing the final step of hepatic triglyceride biosynthesis from DAG (Monetti et al., 2007). Here, DGAT2 is linked to metabolic dysfunction-associated steatotic liver disease.