PNPLA3 and Cirrhosis: PNPLA3 rs738409 GG gene variant carriers have 73% more liver fat, a 3.2-fold higher risk of liver necro-inflammation (Sookoian and Pirola, 2011), and a 1.9-fold higher risk of cirrhosis than PNPLA3 wild-type CC genotype carriers (Shen et al., 2015).