However, the TM6SF2 gene variant is reported to be accompanied by conserved insulin sensitivity and lower serum triglyceride levels in two Finnish cohorts (Zhou et al., 2015; Sliz et al., 2018), a 20−40% increase in the incidence of T2D in the METSIM and FINRISK studies (Kim et al., 2017), and a small increase in the risk of diabetes in 452,244 individuals from 54 studies (OR 1.07 [1.05−1.10], P = 4.8 × 10−12) (Mahajan et al., 2018). Here, INS is linked to type 2 diabetes mellitus.