Insulin sensitivity, as determined by the homeostasis model assessment for insulin resistance (HOMA-IR) or an oral glucose tolerance test, is not reduced in TM6SF2 gene variant carriers (Zhou et al., 2015), and serum triglyceride and LDL cholesterol concentrations are lower compared with non-carriers (Sliz et al., 2018). The gene discussed is INS; the disease is Insulin resistance.