CFL1 and Alzheimer disease: Cofilin and actin can form rod-like structures within neurites of AD brain (Minamide et al., 2000), and their dysfunction may mediate the loss of synapses, and production of the hallmark pathological features of AD: excess Aβ and NFTs (Maloney and Bamburg, 2007; Bamburg and Bernstein, 2016).