In addition, most of above studies involved in AD either did not differentiate cofilin 1 from cofilin 2 (Whiteman et al., 2009; Rahman et al., 2014; Woo et al., 2015a; Deng et al., 2016; Shaw and Bamburg, 2017), or have only focused on cofilin 1 (Barone et al., 2014; Rush et al., 2018), but only few has concerned about cofilin 2 in AD. This evidence concerns the gene CFL1 and Alzheimer disease.