MAPT and frontotemporal dementia: However, a strong consensus on the impact of the FTD mutations in a cellular context has not yet been reached, since in neuroblastoma and CHO cells transfected with GFP-tagged Tau DNA constructs, the co-localization with MTs and generation of MT bundles were shown to be identical for both mutants and wild type Tau (DeTure et al., 2000).