NFE2L2 and Reduced sperm motility: Zhang et al. (2015) suggested that low lncRNA Hox transcript antisense intergenic RNA (HOTAIR) expression was associated with down-regulation of Nrf2 in the spermatozoa of patients with asthenozoospermia or oligoasthenozoospermia. Wang et al. (2017) demonstrated that the functional interaction between lncRNA-MEG3 and Nrf2 constitutes the mechanism by which TGF-β2 induces Tenon’s capsule fibroblast proliferation after glaucoma filtration surgery via the direct binding of MEG3 to Nrf2.