Additionally, Nrf2 is activated in all these neurodegenerative diseases, and Nrf2 activity varies in the regions associated with Alzheimer’s disease, with a tendency for greater Nrf2 activity in the hippocampus and less activity in the frontal cortex (Joshi et al., 2015; Liddell, 2017). Here, NFE2L2 is linked to early-onset autosomal dominant Alzheimer disease.