TBK1 and amyotrophic lateral sclerosis: LOF mutations in TBK1 lead to 50% reduction of TBK1, which is associated with clinical ALS and FTD, and inherited in families in an autosomal dominant pattern (Freischmidt et al., 2015; Gijselinck et al., 2015; Van Mossevelde et al., 2016, 2018; van der Zee et al., 2017).