Among the first reports of mouse PSC used as cell therapy in animal models of stroke, Bühnemann et al. (2006) found that PSC-derived neural precursors transplanted into an Endothelin-1 (ET-1)-induced corticostriatal ischemic lesion, or in the perilesional striatum in rats, survived for up to 12 weeks and differentiated into distinct neuronal subtypes without expressing a specific cortical area-specific identity. The gene discussed is EDN1; the disease is stroke disorder.