CD274 and neoplasm: Although anti-PD-L1 mAb single agent only presented a marginal effect on NKG2D expression on CD8 T cells, combination therapy of anti-PD-L1 mAb and B10G5 resulted in an increase in the frequency of NKG2D+ CD8 T cells in draining LN and tumor infiltrates as compared to B10G5 single agent (Fig. 5a and b).