Our pathway enrichment analysis showed that these abnormally expressed mRNAs were closely related to the PI3K-Akt signaling, cytokine–cytokine receptor interaction, mTOR signaling, chemokine signaling, JAK-STAT signaling, and MAPK signaling pathways, most of which are closely related to the progression of atherosclerosis. Here, AKT1 is linked to atherosclerosis.