The five permanent CTC cell lines, namely BHGc7, 10, 16, 26 and UHGc5, express the typical SCLC markers, such as CD56/NCAM, enolase-2, chromogranin, synaptophysin and EpCAM (except UHGc5), as well as unique mutations of p53 [35, 43]. The gene discussed is NCAM1; the disease is small cell lung carcinoma.