In the Gumz Renal dataset (n=20), significant amplification of PLOD2 was detected in ccRCC tissues compared with normal tissues (4.249-fold, p=4.65−08), and similarly, the Higgins Renal dataset (n=29) showed a 4.721-fold increase in PLOD2 (p=4.89−05) and 2.322-fold increase in PLOD3 mRNA (p=2.00−03) in ccRCC samples compared with normal kidney tissue. Here, PLOD2 is linked to nonpapillary renal cell carcinoma.