In the Beroukhim Renal dataset, PLOD2 and PLOD3 were significantly overexpressed in non-hereditary ccRCC tissues (5.512-fold, p=6.57−12 and 1.719, p=3.59−08, respectively) (n=38) and in hereditary ccRCC tissues (6.562-fold, p=4.15−13 and 2.007, p=3.75−10, respectively) (n=43) compared with normal tissues. Here, PLOD2 is linked to nonpapillary renal cell carcinoma.