IL10 and asthma: The cytokine IL-10 can regulate diverse TH cell responses to limit immunopathology,11 including T2 immunity in murine models of asthma.31, 32 However, there is increasing evidence of heterogeneous asthma phenotypes in human subjects in whom dysfunctional T2 immunity is not the sole immunologic feature, and it is not known how such T2-low/non-T2 immunity is regulated in the setting of asthma.