Finally, to further explore the relationship between the A2AR export via EV and hyperhomocysteinemia, we compared on a same blot the A2AR content of the EV from 6 healthy individuals (Reference Letters C‐H) with normal level of HCy taken as controls with that of 6 CAD patients (Reference Numbers 9‐14) with moderate hyperhomocysteinemia (Table1). The gene discussed is ADORA2A; the disease is coronary artery disorder.