Circulating EV can be considered as a reserve of functional G protein‐coupled receptors as previously suggested from data obtained on a mouse model of heart cellular stress for angiotensin II type 1 receptor.16 Taking into account the major role of A2AR in cardiovascular disease and the potential contribution of circulating EV in delivering cell receptor from donor to target cells, we searched for the presence of A2AR in EV from plasma of patients with CAD and culture supernatant of human lymphoblastoid T cells cultured in CAD‐like conditions. Here, ADORA2A is linked to cardiovascular disorder.