ADORA2A and cancer: These results are in agreement with our previous observation that A2AR cell expression in hypoxia condition is down‐regulated by H2S produced from HCy via the transsulfuration pathway.14 In adenosinergic signalling, exoenzymes CD39 and CD73 are expressed in cancer exosomes where they produce adenosine, which inhibits T cell functions in tumour environment.25 In CAD, one could hypothesize that A2AR circulate from donor cells to target cells as a salvage pathway to be stimulated by adenosine when vasodilation is required for oxygen delivery in failing artery tissues.