Interestingly, SERCA dysfunction, SERCA2a tyrosine nitration, and PLN dysregulation have all been implicated in DCM pathology (Kelley et al., 1991; Lokuta et al., 2005; Kranias and Evangelia,; Jefferies and Towbin, 2010; Acehan et al., 2011). The gene discussed is PLN; the disease is familial dilated cardiomyopathy.