In lesions with coexisting glandular and squamous premalignant components (AIS/SIL; Figure 3), the glandular component in eight of 10 synchronous lesions expressed predominantly SOX17 (Figure 3B), whereas the squamous component exclusively expressed SOX2 in seven of the 10 cases (Figure 3C). This evidence concerns the gene SOX2 and squamous cell intraepithelial neoplasia.