The promoter CpG island region of SOX17 has been reported to be methylated in the majority of squamous and glandular (pre)malignant lesions of the uterine cervix.26 As a single marker, promoter CpG island methylation of SOX17 has been shown to be associated with progression of high‐grade SIL (HSIL) into carcinoma.27 Another transcription regulator protein from the SRY‐box gene family, SOX2, has been shown to play an important role during the progression of SIL lesions. This evidence concerns the gene SOX17 and squamous cell intraepithelial neoplasia.