The change in the passage time of whole blood, which is significantly correlated with the adhesive leukocyte number and plasma levels of MPO, was calculated using BWA-MCFAN by subtraction of the passage time of whole blood treated with EDTA-2Na + heparin from that of blood treated with heparin only, even in blood from patients with DM and ACS, who suffered from inflammation. This evidence concerns the gene MPO and diabetes mellitus.