Oncolytic adenoviruses(OAds) can selectively replicate in cancer cells while sparing normal cells;thus, these viruses have been used in clinical trials for anticancer therapy.El-Shemi et al. applied systemic therapy with Ad-ΔB/ING4 (inhibitor of growth 4)plus Ad-ΔB/TRAIL in an orthotopic human hepatocellular carcinoma (HCC) -bearingmouse model. Here, TNFSF10 is linked to hepatocellular carcinoma.