Ge et al. demonstrated that an oncolytic adenoviruscoexpressing TRAIL and Smac, in combination with the cyclin-dependent kinase(CDK) inhibitor SNS-032, synergistically reinforced their individualanti-pancreatic cancer activities, and SNS-032 enhancedZD55-TRAIL-IETD-Smac-induced apoptosis [131]. Here, TNFSF10 is linked to familial pancreatic carcinoma.