TNFSF10 and neoplasm: A targeted iron oxide NP coatedwith a chitosan-PEG-PEI copolymer and chlorotoxin was developed; this NPefficiently delivered pTRAIL into human T98G GBM cells and induced thesecretion of TRAIL [59].Further, systemic administration to mice bearing T98G-derived flankxenografts resulted in almost imperceptible tumor growth and inducedapoptosis in tumor tissue.