It is also plausible that other brain regions not targeted in CaMK-PB2−/− mice (i.e., beyond the forebrain), but affected in the constitutive and global Sema4C−/− and PB2−/−, PB2-LOFRhoA mutants, come into play in regulating auditory-cued fear memory and anxiety. This evidence concerns the gene CAMK2G and Anxiety.