The MTMR3 rs9983 high-risk allele at 22q12 showed associations with lupus nephritis, with lower MTMR3 transcription levels were recorded in blood samples with the rs9983 high-risk allele and in renal biopsies from lupus nephritis and IgA nephropathy patients20. This evidence concerns the gene MTMR3 and IgA glomerulonephritis.