Furthermore, we found that rs12537 TT homozygosity was associated with the lowest expression levels of MTMR3 mRNA among RA and SLE patients which superimposed the highest levels of the autophagy marker, LC3B, linking MTMR3 to the deregulated autophagy in RA and SLE. The gene discussed is MTMR3; the disease is systemic lupus erythematosus.