Among all 140 patients with lung adenocarcinoma, low cytoplasmic AK1 IHC immunoreactivity (score 0 and score 1) was observed in 58 (41.4%) cases while strong cytoplasmic AK1 IHC immunoreactivity (score 2 and score 3) was detected in 82 (58.6%) cases (Fig. 2a, upper panel). The gene discussed is AK1; the disease is lung adenocarcinoma.