AK4 and lung adenocarcinoma: To investigate the molecular profiles of each AK-associated gene signatures, we performed co-expression analysis individually for AK1, AK2, AK3, AK4, AK5, AK7, AK8, and AK9 using TCGA lung adenocarcinoma (LUAD) dataset and identified unique signatures for each AK (Fig. 1a and Supplementary Table S1).