ICAM1 and cancer: CD54 (ICAM1), a member of the immunoglobulin supergene family, was found to be involved in the cross-reactive cellular uptake of DOX@E-PSiNPs by cancer cells, as evidenced by the fact that DOX@E-PSiNPs exocytosed from B16-F10 and H22 cells expressed CD54 (Supplementary Fig. 19a), and pretreatment with CD54 antibody decreased the cellular uptake of DOX@E-PSiNPs exocytosed from H22 cells by H22 and B16-F10 cells (Supplementary Fig. 19b).