TP53 and hematologic disorder: In the present study, mir-15b-5p, miR-146a-5p and miR-328 were down-regulated in SCI individuals and our in silico analysis identified several potential targets genes regulated for these miRNAs, including the oncogene PIM1 [24], while miR-125b was up-regulated in SCI individuals and in silico analysis revealed nine target genes as potential targets of this miRNA associated with hematological disease, including tumor suppressor genes such as TP53, STAT3 and TCF7 [27].